Article
Genetic diversity and recombination at the C-terminal fragment of the merozoite surface protein-1 of Plasmodium vivax (PvMSP-1) in Sri Lanka.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jan 2011
Dias Sajani, Longacre Shirley, Escalante Ananias A, Udagama-Randeniya Preethi V
Abstract excerpt
Extensive polymorphism in the genes encoding for surface antigens of Plasmodium falciparum and Plasmodium vivax has been a serious impediment for malaria vaccine development. One such antigen is the merozoite surface protein-1 (MSP-1). The MSP-1 precursor after proteolytic cleavage generates a C-terminal fragment of 42 kDa (MSP-1(42)), which subsequently produces 33 kDa (MSP-1(33)) and 19 kDa (MSP-1(19))...
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