Article
Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation.
Cell reports - 8 Sept 2020
Grubišić Vladimir, McClain Jonathon L, Fried David E, Grants Iveta, Rajasekhar Pradeep, Csizmadia Eva, Ajijola Olujimi A, Watson Ralph E, Poole Daniel P, Robson Simon C, Christofi Fievos L, Gulbransen Brian D
Abstract excerpt
Mechanisms resulting in abdominal pain include altered neuro-immune interactions in the gastrointestinal tract, but the signaling processes that link immune activation with visceral hypersensitivity are unresolved. We hypothesized that enteric glia link the neural and immune systems of the gut and that communication between enteric glia and immune cells modulates the development of visceral hypersensitivity. To...
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