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Article

Dysregulated serum response factor triggers formation of hepatocellular carcinoma.

Hepatology (Baltimore, Md.) - 1 Mar 2015

Ohrnberger Stefan, Thavamani Abhishek, Braeuning Albert, Lipka Daniel B, Kirilov Milen, Geffers Robert, Autenrieth Stella E, Authenrieth Stella E, Römer Michael, Zell Andreas, Bonin Michael, Schwarz Michael, Schütz Günther, Schirmacher Peter, Plass Christoph, Longerich Thomas, Nordheim Alfred

Abstract excerpt

UNLABELLED: The ubiquitously expressed transcriptional regulator serum response factor (SRF) is controlled by both Ras/MAPK (mitogen-activated protein kinase) and Rho/actin signaling pathways, which are frequently activated in hepatocellular carcinoma (HCC). We generated SRF-VP16iHep mice, which conditionally express constitutively active SRF-VP16 in hepatocytes, thereby controlling subsets of both Ras/MAPK- and...

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Identifiers

PMID: 25266280
DOI: 10.1002/hep.27539
PMCID: PMC4365683

Genes

SRF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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