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Targeting AATF reprograms the tumor microenvironment and suppresses hepatocellular carcinoma via MIR100HG–TGF-β signaling

2026-05-20

Abstract excerpt

Hepatocellular carcinoma (HCC), a leading cause of cancer death, has a dynamic and heterogeneous tumor microenvironment (TME) that drives progression and therapeutic resistance. We previously elucidated that apoptosis antagonizing transcription factor (AATF) drives angiogenesis in HCC. However, its role in TME remains unexplored. We employed an orthotopic xenograft mouse model, implanting human HCC cells into the...

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Literature Corpus work
ab20e4d1-07b5-5509-b3e8-c2ed1595e6e4
DOI
10.64898/2026.05.17.725764
Open publication

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Targeting AATF reprograms the tumor microenvironment and suppresses hepatocellular carcinoma via MIR100HG–TGF-β signalingDOI 10.64898/2026.05.17.725764
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