Article
BRAF inhibition increases TGFβ2 production and stimulates metastasis in mice with endogenous BRAFV600E-induced hepatocellular carcinoma.
Proceedings of the National Academy of Sciences of the United States of America - 11 Nov 2025
Cisowski Jaroslaw, El Zowalaty Ahmed Ezat, Sayin Sama I, Czarnota Piotr, Gromowski Tomasz, Eklund Ella A, Kashif Muhammad, Patel Angana A H, Molinaro Antonio, Lindahl Per, Wiel Clotilde, Sayin Volkan I, Bergo Martin O
Abstract excerpt
The MEK-ERK pathway is a key driver of hepatocellular carcinoma (HCC) pathogenesis, and BRAF mutations, particularly BRAFV600E, can contribute to its activation. Although BRAFV600E mutations are rare in human HCC, they do occur, yet their physiologic impact in liver cells, especially when combined with frequent comutations in tumor suppressor genes, remains poorly understood. Moreover, the effect of BRAF...
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