Article

Transposable element profiles reveal cell line identity and loss of heterozygosity in <i>Drosophila</i> cell culture

2021-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Cell culture systems allow key insights into biological mechanisms yet suffer from irreproducible outcomes in part because of cross-contamination or mislabelling of cell lines. Cell line misidentification can be mitigated by the use of genotyping protocols, which have been developed for human cell lines but are lacking for many important model species. Here we leverage the classical observation...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 51dd3928-8085-5f9d-8149-43827227dd91
DOI: 10.1101/2021.04.24.441253

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transposable element profiles reveal cell line identity and loss of heterozygosity in <i>Drosophila</i> cell cultureDOI 10.1101/2021.04.24.441253Read

A novel transposable element based authentication protocol for <i>Drosophila</i> cell linesSemantic proximity Read

Local assembly of long reads enables phylogenomics of transposable elements in a polyploid cell lineSemantic proximity Read

Unique transposon landscapes are pervasive across Drosophila melanogaster genomes.Semantic proximity Read

Population-scale long-read sequencing uncovers transposable elements contributing to gene expression variation and associated with adaptive signatures in <i>Drosophila melanogaster</i>Semantic proximity Read

Expression of retrotransposons contributes to aging in <i>Drosophila</i>Semantic proximity Read

Identification and quantification of transposable element transcripts using Long-Read RNA-seq in <i>Drosophila</i> germline tissuesSemantic proximity Read

Dynamics and impacts of transposable element proliferation during the <i>Drosophila nasuta</i> species group radiationSemantic proximity Read

Somatic transposition in the <i>Drosophila</i> intestine occurs in active chromatin and is associated with tumor suppressor gene inactivationSemantic proximity Read

Genomic analysis of <i>P</i> elements in natural populations of <i>Drosophila melanogaster</i>Semantic proximity Read

Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines.Semantic proximity Read

LINE-1 Retrotransposon expression in cancerous, epithelial and neuronal cells revealed by 5’ single-cell RNA-SeqSemantic proximity Read

piRNA loss unleashes episodic transposition burstsSemantic proximity Read