Article
The Evolution of Human Cancer Gene Duplications across Mammals
2020-03-05
Abstract excerpt
Cancer is caused by genetic alterations that affect cellular fitness, and multicellular organisms have evolved mechanisms to suppress cancer such as cell cycle checkpoints and apoptosis. These pathways may be enhanced by the addition of tumor suppressor gene paralogs or deletion of oncogenes. To provide insights to the evolution of cancer suppression across the mammalian radiation, we estimated copy numbers for 54...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 7bf47c6f-e433-588f-b587-d77a85c13f8e
- DOI
- 10.1101/2020.03.05.978965