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Article

Characterising the Phenotypic Diversity of Antigen-Specific Memory B Cells Before and After Vaccination.

Frontiers in immunology - 1 Jan 2021

Tjiam M Christian, Fernandez Sonia, French Martyn A

Abstract excerpt

The diversity of B cell subsets and their contribution to vaccine-induced immunity in humans are not well elucidated but hold important implications for rational vaccine design. Prior studies demonstrate that B cell subsets distinguished by immunoglobulin (Ig) isotype expression exhibit divergent activation-induced fates. Here, the antigen-specific B cell response to tetanus toxoid (TTd) booster vaccination was...

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Identifiers

PMID: 34650561
DOI: 10.3389/fimmu.2021.738123
PMCID: PMC8505969

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