Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2

Abstract excerpt

Abstract The B cell response to different pathogens uses tailored effector mechanisms and results in functionally specialized memory B (Bm) cell subsets, including CD21+ resting, CD21–CD27+ activated and CD21–CD27– Bm cells. The interrelatedness between these Bm cell subsets remains unknown. Here we showed that single severe acute respiratory syndrome coronavirus 2-specific Bm cell clones showed plasticity upon...

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