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Article

TLR7- and TLR9-responsive human B cells share phenotypic and genetic characteristics.

Journal of immunology (Baltimore, Md. : 1950) - 1 Apr 2015

Simchoni Noa, Cunningham-Rundles Charlotte

Abstract excerpt

B cells activated by nucleic acid-sensing TLR7 and TLR9 proliferate and secrete immune globulins. Memory B cells are presumably more responsive due to higher TLR expression levels, but selectivity and differential outcomes remain largely unknown. In this study, peripheral blood human B cells were stimulated by TLR7 or TLR9 ligands, with or without IFN-α, and compared with activators CD40L plus IL-21, to identify...

Read the complete abstract on PubMed

Topics

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Share to B-Lymphocyte Subsets
Share to CD40 Ligand
Share to Complementarity Determining Regions

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-21

Share to Plasma Cells

Share to Somatic Hypermutation, Immunoglobulin

Share to Toll-Like Receptor 7

Share to Toll-Like Receptor 9

Source

Open in PubMed Open full text

Identifiers

PMID: 25740945
DOI: 10.4049/jimmunol.1402690
PMCID: PMC4369401

Genes

TLR7
TLR9
BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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