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Article

Multiple mucin depleted foci, high proliferation and low apoptotic response in the onset of colon carcinogenesis of the PIRC rat, mutated in Apc.

International journal of cancer - 15 Mar 2015

Femia Angelo Pietro, Luceri Cristina, Soares Paulo Victoria, Lodovici Maura, Caderni Giovanna

Abstract excerpt

PIRC rats (F344/NTac-Apc (am1137) ) mutated in the Apc gene spontaneously develop colon tumors thus mimicking familial adenomatous polyposis (FAP) and sporadic colorectal cancer (CRC) more closely than Apc-based rodent models developing tumors mostly in the small intestine. To understand whether microscopic dysplastic lesions precede the development of macroscopic tumors, PIRC rat colon was examined for the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25257656
DOI: 10.1002/ijc.29232

Genes

FAP
PCNA

Provenance

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