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Article

Characterization of dysplastic aberrant crypt foci in the rat colon induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

The American journal of pathology - 1 Oct 2003

Ochiai Masako, Ushigome Mitsunori, Fujiwara Kyoko, Ubagai Tsuneyuki, Kawamori Toshihiko, Sugimura Takashi, Nagao Minako, Nakagama Hitoshi

Abstract excerpt

The multistage model of colon carcinogenesis is well established in both humans and experimental animals, and aberrant crypt foci (ACF) are generally assumed to be putative preneoplastic lesions of the colon. However, morphological analyses of ACF have suggested that they are highly heterogeneous in nature and their role in tumorigenesis is still controversial. To better understand the biological significance of...

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Identifiers

PMID: 14507667
DOI: 10.1016/S0002-9440(10)63517-1
PMCID: PMC1868301

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