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Article

DNA damage in colon mucosa of Pirc rats, an Apc-driven model of colon tumorigenesis.

Toxicology letters - 15 May 2020

Tortora Katia, Vitali Francesco, De Filippo Carlotta, Caderni Giovanna, Giovannelli Lisa

Abstract excerpt

APC mutation is the first event triggering colon carcinogenesis (CRC). The contribution of APC to colon mucosa DNA damage is not well characterized yet. Similarly, the role of genotoxin-producer gut microorganisms is unclear. DNA strand breaks and oxidative damage were measured in Pirc rats, mutated in Apc, with the COMET assay at age 1 (T1) and 11 months (T11), i.e. in absence and presence of colon adenomas. In...

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Identifiers

PMID: 32035981
DOI: 10.1016/j.toxlet.2020.02.002

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