Article
Thrombospondin-1 is part of a Slug-independent motility and metastatic program in cutaneous melanoma, in association with VEGFR-1 and FGF-2.
Pigment cell & melanoma research - 1 Jan 2015
Borsotti Patrizia, Ghilardi Carmen, Ostano Paola, Silini Antonietta, Dossi Romina, Pinessi Denise, Foglieni Chiara, Scatolini Maria, Lacal Pedro M, Ferrari Raffaele, Moscatelli Davide, Sangalli Fabio, D'Atri Stefania, Giavazzi Raffaella, Bani Maria Rosa, Chiorino Giovanna, Taraboletti Giulia
Abstract excerpt
Differently from most transformed cells, cutaneous melanoma expresses the pleiotropic factor thrombospondin-1 (TSP-1). Herein, we show that TSP-1 (RNA and protein), undetectable in four cultures of melanocytes and a RGP melanoma, was variously present in 13 cell lines from advanced melanomas or metastases. Moreover, microarray analysis of 55 human lesions showed higher TSP-1 expression in primary melanomas and...
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