Article
Thrombospondin-1 and cutaneous melanoma.
Journal of cutaneous medicine and surgery - 1 Jan 2000
Trotter M J, Colwell R, Tron V A
Abstract excerpt
BACKGROUND: Thrombospondins (TSPs) are recognized as important glycoproteins that regulate a wide variety of cell functions and interactions. TSPs in malignant tumors can both enhance and inhibit tumor progression, invasion, and metastasis, depending on cell type, stromal interactions, and microenvironment. These proteins are potential targets for anticancer therapy. OBJECTIVE: The aim of our article is to review...
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