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Article

Thrombospondin 1 promotes an aggressive phenotype through epithelial-to-mesenchymal transition in human melanoma.

Oncotarget - 30 Jul 2014

Jayachandran Aparna, Anaka Matthew, Prithviraj Prashanth, Hudson Christopher, McKeown Sonja J, Lo Pu-Han, Vella Laura J, Goding Colin R, Cebon Jonathan, Behren Andreas

Abstract excerpt

Epithelial-to-mesenchymal transition (EMT), in which epithelial cells loose their polarity and become motile mesenchymal cells, is a determinant of melanoma metastasis. We compared gene expression signatures of mesenchymal-like melanoma cells with those of epithelial-like melanoma cells, and identified Thrombospondin 1 (THBS1) as highly up-regulated in the mesenchymal phenotype. This study investigated whether...

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Source

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Identifiers

PMID: 25051363
DOI: 10.18632/oncotarget.2164
PMCID: PMC4170613

Genes

THBS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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