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Metastasis suppressor <scp>NME</scp>1 regulates melanoma cell morphology, self‐adhesion and motility via induction of fibronectin expression

24 Mar 2015

Abstract excerpt

Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility and invasion in vitro and metastasis in vivo, but the underlying molecular mechanisms are not completely understood. Herein, we report a novel mechanism through which NME1 controls melanoma cell morphology via upregulation of the extracellular matrix (ECM) protein fibronectin. Expression of NME1 strongly...

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PMID: 25808322
DOI: 10.1111/exd.12697

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