GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.

doi:10.1016/j.humimm.2012.06.009

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Article

GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.

Human immunology - 1 Sept 2012

Kang Mi-Jin, Yu Ho-Sung, Seo Ju-Hee, Kim Hyung-Young, Jung Young-Ho, Kim Young-Joon, Kim Ha-Jung, Lee So-Yeon, Hong Soo-Jong

Abstract excerpt

In 2007, a genome-wide association study identified associations between variants involved in the regulation of ORMDL3 expression and asthma. These observations were subsequently replicated in case-control studies in several ethnic groups. We investigated the possible contribution of GSDMB/ORMDL3 variants to asthma susceptibility and intermediate asthma phenotypes in Korean children. The polymorphisms rs7216389,...

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Identifiers

PMID: 22732088
DOI: 10.1016/j.humimm.2012.06.009

Genes

ORMDL3
GSDMB
FEV

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GSDMB/ORMDL3 variants contribute to asthma susceptibility and eosinophil-mediated bronchial hyperresponsiveness.PMID 22732088Read ↗

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