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Article

Whole-genome sequencing identifies genetic variances in culture-expanded human mesenchymal stem cells.

Stem cell reports - 12 Aug 2014

Cai Jun, Miao Xuexia, Li Yueying, Smith Cory, Tsang Kitman, Cheng Linzhao, Wang Qian-Fei

Abstract excerpt

Culture-expanded human mesenchymal stem cells (MSCs) are increasingly used in clinics, yet full characterization of the genomic compositions of these cells is lacking. We present a whole-genome investigation on the genetic dynamics of cultured MSCs under ex vivo establishment (passage 1 [p1]) and serial expansion (p8 and p13). We detected no significant changes in copy-number alterations (CNAs) and low levels of...

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Identifiers

PMID: 25254336
DOI: 10.1016/j.stemcr.2014.05.019
PMCID: PMC4176531

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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