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Article

Passage-dependent accumulation of somatic mutations in mesenchymal stromal cells during in vitro culture revealed by whole genome sequencing.

Scientific reports - 6 Nov 2017

Kim Myungshin, Rhee Je-Keun, Choi Hayoung, Kwon Ahlm, Kim Jiyeon, Lee Gun Dong, Jekarl Dong Wook, Lee Seungok, Kim Yonggoo, Kim Tae-Min

Abstract excerpt

Human mesenchymal stromal cells (MSCs) have served as a major cellular resource for cell-based immunomodulatory and regenerative therapies. However, genomic instability may accumulate during ex vivo expansion of MSCs, thereby increasing the potential of malignant transformation. Here, we performed whole genome sequencing of two peripheral blood-derived MSC lines (MSC1 and MSC2) at various passages (passage 1 [P1]...

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Identifiers

PMID: 29109420
DOI: 10.1038/s41598-017-15155-5
PMCID: PMC5674020

Genes

MSC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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