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Article

Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity.

Journal of pediatric gastroenterology and nutrition - 1 Oct 2014

Marzuillo Pierluigi, Grandone Anna, Conte Mariasole, Capuano Francesco, Cirillo Grazia, Di Sessa Anna, Umano Giuseppina R, Romano Roberta, Perrone Laura, del Giudice Emanuele Miraglia

Abstract excerpt

The G-protein-coupled receptor 120 (GPR120) is a receptor for polyunsaturated fatty acids with anti-inflammatory activity. The R270H variant of GPR120 enhances inflammation in adipose and hepatic tissues. We investigated whether the R270H variant could play a role in determining liver injury in children and adolescents with obesity. Five hundred eighty-one children with obesity were studied. No homozygotes and 20...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, G-Protein-Coupled

Source

Identifiers

PMID: 25250621
DOI: 10.1097/MPG.0000000000000463

Genes

PNPLA3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity.PMID 25250621Read ↗

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