Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.

doi:10.1016/j.gene.2013.03.038

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Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.

Gene - 15 May 2013

Larrieta-Carrasco Elena, León-Mimila Paola, Villarreal-Molina Teresa, Villamil-Ramírez Hugo, Romero-Hidalgo Sandra, Jacobo-Albavera Leonor, Gutiérrez-Vidal Roxana, López-Contreras Blanca E, Guillén-Pineda Luz E, Sánchez-Muñoz Fausto, Bojalil Rafael, Mejía-Domínguez Ana M, Méndez-Sánchez Nahúm, Domínguez-López Aaron, Aguilar-Salinas Carlos A, Canizales-Quinteros Samuel

Abstract excerpt

BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. The aims of this study were to estimate the frequency of elevated ALT levels, and to address the influence of obesity and...

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PMID: 23510779
DOI: 10.1016/j.gene.2013.03.038

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PNPLA3

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Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.PMID 23510779Read ↗

PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations.Semantic proximity Read ↗

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.Semantic proximity Read ↗

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.Semantic proximity Read ↗

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Semantic proximity Read ↗

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.Semantic proximity Read ↗

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Semantic proximity Read ↗

Nonalcoholic fatty liver disease and eGFR levels could be linked by the PNPLA3 I148M polymorphism in children with obesitySemantic proximity Read ↗

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.Semantic proximity Read ↗

Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.Semantic proximity Read ↗

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