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Article

Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.

Gene - 15 May 2013

Larrieta-Carrasco Elena, León-Mimila Paola, Villarreal-Molina Teresa, Villamil-Ramírez Hugo, Romero-Hidalgo Sandra, Jacobo-Albavera Leonor, Gutiérrez-Vidal Roxana, López-Contreras Blanca E, Guillén-Pineda Luz E, Sánchez-Muñoz Fausto, Bojalil Rafael, Mejía-Domínguez Ana M, Méndez-Sánchez Nahúm, Domínguez-López Aaron, Aguilar-Salinas Carlos A, Canizales-Quinteros Samuel

Abstract excerpt

BACKGROUND AND AIMS: Non-alcoholic fatty liver disease (NAFLD) and elevated alanine transaminase (ALT) levels are common in obese Hispanic adults and children. Recently, a PNPLA3 gene variant (I148M) was strongly associated with NAFLD and higher ALT levels in obese adults, including Hispanics. Th...

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Source

Identifiers

PMID: 23510779
DOI: 10.1016/j.gene.2013.03.038

Genes

PNPLA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23510779-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.PMID 23510779Read ↗

PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations.Semantic proximity Read ↗

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.Semantic proximity Read ↗

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.Semantic proximity Read ↗

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Semantic proximity Read ↗

The PNPLA3 I148M polymorphism is associated with insulin resistance and nonalcoholic fatty liver disease in a normoglycaemic population.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

I148M variant in PNPLA3 reduces central adiposity and metabolic disease risks while increasing nonalcoholic fatty liver disease.Semantic proximity Read ↗

Association of PNPLA3 I148M with Liver Disease Biomarkers in Latinos.Semantic proximity Read ↗

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Semantic proximity Read ↗

Nonalcoholic fatty liver disease and eGFR levels could be linked by the PNPLA3 I148M polymorphism in children with obesitySemantic proximity Read ↗

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.Semantic proximity Read ↗

Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults.Semantic proximity Read ↗

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