Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.

doi:10.1111/ijpo.234

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Article

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.

Pediatric obesity - 1 Apr 2015

Viitasalo A, Pihlajamaki J, Lindi V, Atalay M, Kaminska D, Joro R, Lakka T A

Abstract excerpt

OBJECTIVES: PNPLA3 I148M polymorphism (rs738409) has been strongly associated with liver fat content and plasma alanine aminotransferase (ALT) levels in obese adults and children, but little is known about these relationships in normal weight individuals. We studied the associations and interactions of overweight and the PNPLA3 I148M polymorphism with plasma ALT levels during 2-year follow-up in children....

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PMID: 24916969
DOI: 10.1111/ijpo.234

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PNPLA3

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Related research

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Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.PMID 24916969Read ↗

Association of the I148M/PNPLA3 variant with elevated alanine transaminase levels in normal-weight and overweight/obese Mexican children.Semantic proximity Read ↗

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Semantic proximity Read ↗

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.Semantic proximity Read ↗

Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.Semantic proximity Read ↗

PNPLA3 I148M Interacts With Environmental Triggers to Cause Human Disease.Semantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

PNPLA3 I148M polymorphism is associated with elevated alanine transaminase levels in Mexican Indigenous and Mestizo populations.Semantic proximity Read ↗

Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese childrenSemantic proximity Read ↗

Influence of genetics on clinical trajectories in children with MASLD: role of the PNPLA3 I148M polymorphism.Semantic proximity Read ↗

PNPLA3 I148M Polymorphism in Patients with Nonalcoholic Fatty Liver Disease, Obesity and Prediabetes.Semantic proximity Read ↗

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