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Article

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.

PloS one - 1 Jan 2011

Giudice Emanuele Miraglia del, Grandone Anna, Cirillo Grazia, Santoro Nicola, Amato Alessandra, Brienza Carmine, Savarese Piera, Marzuillo Pierluigi, Perrone Laura

Abstract excerpt

BACKGROUND AND AIMS: A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity. Aims of this study were i) to analyse in a large group of obese children the role of the interaction of not-genetic factors such as BMI, waist circumference (W/Hr) and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22140488
DOI: 10.1371/journal.pone.0027933
PMCID: PMC3225386

Genes

PNPLA3
SDS

Variants

rs738409

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The association of PNPLA3 variants with liver enzymes in childhood obesity is driven by the interaction with abdominal fat.PMID 22140488Read ↗

Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese childrenSemantic proximity Read ↗

The 148M allele of the PNPLA3 gene is associated with indices of liver damage early in life.Semantic proximity Read ↗

Patatin-like phospholipase 3 (rs738409) gene polymorphism is associated with increased liver enzymes in obese adolescents and metabolic syndrome in all ages.Semantic proximity Read ↗

The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study.Semantic proximity Read ↗

Effect of the patatin-like phospholipase domain containing 3 gene (PNPLA3) I148M polymorphism on the risk and severity of nonalcoholic fatty liver disease and metabolic syndromes: A meta-analysis of paediatric and adolescent individuals.Semantic proximity Read ↗

I148M patatin-like phospholipase domain-containing 3 gene variant and severity of pediatric nonalcoholic fatty liver disease.Semantic proximity Read ↗

Associations of I148M variant in PNPLA3 gene with plasma ALT levels during 2-year follow-up in normal weight and overweight children: the PANIC Study.Semantic proximity Read ↗

Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake.Semantic proximity Read ↗

The PNPLA3 I148M variant and chronic liver disease: When a genetic mutation meets nutrientsSemantic proximity Read ↗

Morbid obesity exposes the association between PNPLA3 I148M (rs738409) and indices of hepatic injury in individuals of European descent.Semantic proximity Read ↗

Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease.Semantic proximity Read ↗

Homozygosity for the patatin-like phospholipase-3/adiponutrin I148M polymorphism influences liver fibrosis in patients with nonalcoholic fatty liver disease.Semantic proximity Read ↗

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