Article
A functional nonsynonymous toll-like receptor 4 gene polymorphism is associated with metabolic syndrome, surrogates of insulin resistance, and syndromes of lipid accumulation.
Metabolism: clinical and experimental - 1 May 2010
Steinhardt Alberto Penas, Aranguren Florencia, Tellechea Mariana L, Gómez Rosso Leonardo A, Brites Fernando D, Martínez-Larrad Maria T, Serrano-Ríos Manuel, Frechtel Gustavo D, Taverna Mariano J
Abstract excerpt
Toll-like receptor 4 (TLR4) plays a key role in the activation of innate immune responses. Loss-of-function mutations in TLR4 prevent diet-induced obesity and insulin resistance (IR). We conducted a population cross-sectional study to evaluate whether Asp299Gly (rs4986790) TLR4 gene polymorphism is associated with metabolic syndrome (MS), surrogates of IR, and syndromes of lipid accumulation (SLAs) in Argentinean...
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