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Article

Lack of Association of the APOL1 G3 Haplotype in African Americans with ESRD.

Journal of the American Society of Nephrology : JASN - 1 May 2015

Palmer Nicholette D, Ng Maggie C Y, Langefeld Carl D, Divers Jasmin, Lea Janice P, Okusa Mark D, Kimberly Robert P, Bowden Donald W, Freedman Barry I

Abstract excerpt

Apolipoprotein L1 gene (APOL1) G1 and G2 variants are strongly associated with progressive nondiabetic nephropathy in populations with recent African ancestry. Selection for these variants occurred as a result of protection from human African trypanosomiasis (HAT). Resequencing of this region in 10 genetically and geographically distinct African populations residing in HAT endemic regions identified eight single...

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Identifiers

PMID: 25249559
DOI: 10.1681/ASN.2014050444
PMCID: PMC4413768

Genes

APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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