Article
APOL1 Genotype, Kidney and Cardiovascular Disease, and Death in Older Adults.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2016
Mukamal Kenneth J, Tremaglio Joseph, Friedman David J, Ix Joachim H, Kuller Lewis H, Tracy Russell P, Pollak Martin R
Abstract excerpt
OBJECTIVE: We sought to evaluate the cardiovascular impact of coding variants in the apolipoprotein L1 gene APOL1 that protect against trypanosome infection but have been associated with kidney disease among African Americans. APPROACH AND RESULTS: As part of the Cardiovascular Health Study, a population-based cohort of Americans aged ≥65 years, we genotyped APOL1 polymorphisms rs73885319 and rs71785153 and...
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