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Article

The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.

Journal of the American Society of Nephrology : JASN - 1 Sept 2010

Freedman Barry I, Kopp Jeffrey B, Langefeld Carl D, Genovese Giulio, Friedman David J, Nelson George W, Winkler Cheryl A, Bowden Donald W, Pollak Martin R

Abstract excerpt

Mapping by admixture linkage disequilibrium (LD) detected strong association between nonmuscle myosin heavy chain 9 gene (MYH9) variants on chromosome 22 and nondiabetic nephropathy in African Americans. MYH9-related variants were posited to be the probable, but not necessarily the definitive, causal variants as a result of impressive statistical evidence of association, renal expression, and a role in autosomal...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20688934
DOI: 10.1681/ASN.2010070730
PMCID: PMC7391383

Genes

MYH9
APOL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The apolipoprotein L1 (APOL1) gene and nondiabetic nephropathy in African Americans.PMID 20688934Read ↗

Missense mutations in the APOL1 gene are highly associated with end stage kidney disease risk previously attributed to the MYH9 gene.Semantic proximity Read ↗

Genetic variation in APOL1 and MYH9 genes is associated with chronic kidney disease among Nigerians.Semantic proximity Read ↗

Apolipoprotein L1 gene variants associate with hypertension-attributed nephropathy and the rate of kidney function decline in African Americans.Semantic proximity Read ↗

The population genetics of chronic kidney disease: insights from the MYH9-APOL1 locus.Semantic proximity Read ↗

A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.Semantic proximity Read ↗

MYH9 is associated with nondiabetic end-stage renal disease in African Americans.Semantic proximity Read ↗

APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy.Semantic proximity Read ↗

Differential effects of MYH9 and APOL1 risk variants on FRMD3 Association with Diabetic ESRD in African Americans.Semantic proximity Read ↗

The MYH9/APOL1 region and chronic kidney disease in European-Americans.Semantic proximity Read ↗

Non-muscle myosin heavy chain 9 gene MYH9 associations in African Americans with clinically diagnosed type 2 diabetes mellitus-associated ESRD.Semantic proximity Read ↗

The spectrum of MYH9-associated nephropathy.Semantic proximity Read ↗

APOL1 variants and kidney disease in people of recent African ancestry.Semantic proximity Read ↗

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