Article
Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
Science (New York, N.Y.) - 13 Aug 2010
Genovese Giulio, Friedman David J, Ross Michael D, Lecordier Laurence, Uzureau Pierrick, Freedman Barry I, Bowden Donald W, Langefeld Carl D, Oleksyk Taras K, Uscinski Knob Andrea L, Bernhardy Andrea J, Hicks Pamela J, Nelson George W, Vanhollebeke Benoit, Winkler Cheryl A, Kopp Jeffrey B, Pays Etienne, Pollak Martin R
Abstract excerpt
African Americans have higher rates of kidney disease than European Americans. Here, we show that, in African Americans, focal segmental glomerulosclerosis (FSGS) and hypertension-attributed end-stage kidney disease (H-ESKD) are associated with two independent sequence variants in the APOL1 gene on chromosome 22 {FSGS odds ratio = 10.5 [95% confidence interval (CI) 6.0 to 18.4]; H-ESKD odds ratio = 7.3 (95% CI...
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