Article
Sequencing rare and common APOL1 coding variants to determine kidney disease risk.
Kidney international - 1 Oct 2015
Limou Sophie, Nelson George W, Lecordier Laurence, An Ping, O'hUigin Colm S, David Victor A, Binns-Roemer Elizabeth A, Guiblet Wilfried M, Oleksyk Taras K, Pays Etienne, Kopp Jeffrey B, Winkler Cheryl A
Abstract excerpt
A third of African Americans with sporadic focal segmental glomerulosclerosis (FSGS) or HIV-associated nephropathy (HIVAN) do not carry APOL1 renal risk genotypes. This raises the possibility that other APOL1 variants may contribute to kidney disease. To address this question, we sequenced all APOL1 exons in 1437 Americans of African and European descent, including 464 patients with biopsy-proven FSGS/HIVAN....
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