Article
Carrying APOL1 G1 allele is associated with cardiovascular complications during COVID-19 in an admixed population.
Human genomics - 31 Aug 2025
Cadore Nathan A, Fam Bibiana S de O, Giudicelli Giovanna C, Kowalski Thayne W, Sbruzzi Renan C, Castro E Silva Marcos A, Feira Marilea F, de Souza Célia Mariana B, da Silva Dirceu R, Artigalás Osvaldo, Lemes Renan B, Rodrigues Maíra R, Nunes Kelly, Pereira Alexandre C, Pereira Lygia V, Hünemeier Tábita, Vianna Fernanda S L
Abstract excerpt
BACKGROUND: The APOL1 G1 and G2 alleles were selected in the Sub-Saharan African population by conferring resistance to trypanosome infection. However, these alleles are associated with kidney diseases, and their role in cardiovascular complications remains uncertain. A second hit mediated by an inflammatory state is necessary for APOL1-mediated phenotypes. Thus, this cross-sectional study investigates the...
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