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Article

Opposing effects of CTLA4 insufficiency on regulatory versus conventional T cells in autoimmunity converge on effector memory in target tissue.

Journal of immunology (Baltimore, Md. : 1950) - 1 Nov 2014

Devarajan Priyadharshini, Miska Jason, Lui Jen Bon, Swieboda Dominika, Chen Zhibin

Abstract excerpt

Quantitative variations in CTLA4 expression, because of genetic polymorphisms, are associated with various human autoimmune conditions, including type 1 diabetes (T1D). Extensive studies have demonstrated that CTLA4 is not only essential for the suppressive role of regulatory T cells (T(reg)) but also required for intrinsic control of conventional T (T(conv)) cells. We report that a modest insufficiency of CTLA4...

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Share to CTLA-4 Antigen
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Immunologic Memory

Share to Interleukin-17

Share to Pancreas

Share to Receptors, Interleukin-17

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Source

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Identifiers

PMID: 25246499
DOI: 10.4049/jimmunol.1400876
PMCID: PMC4201963

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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