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Article

CTLA-4: a key regulatory point in the control of autoimmune disease.

Immunological reviews - 1 Jun 2008

Scalapino Kenneth J, Daikh David I

Abstract excerpt

SUMMARY: Chronic autoimmune disease in humans is the result of a failure to control autoreactive immune cells in the periphery. This control is largely achieved by inhibition of newly activated and memory cells. A number of negative immune regulatory pathways have been characterized. The cell surface coreceptor cytotoxic T-lymphocyte antigen-4 (CTLA-4) has emerged as a critical attenuator of T-cell activation and...

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Identifiers

PMID: 18613834
DOI: 10.1111/j.1600-065X.2008.00639.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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