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Article

Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance.

Nature - 28 Jun 2007

Odegaard Justin I, Ricardo-Gonzalez Roberto R, Goforth Matthew H, Morel Christine R, Subramanian Vidya, Mukundan Lata, Red Eagle Alex, Vats Divya, Brombacher Frank, Ferrante Anthony W, Chawla Ajay

Abstract excerpt

Obesity and insulin resistance, the cardinal features of metabolic syndrome, are closely associated with a state of low-grade inflammation. In adipose tissue chronic overnutrition leads to macrophage infiltration, resulting in local inflammation that potentiates insulin resistance. For instance,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17515919
DOI: 10.1038/nature05894
PMCID: PMC2587297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17515919-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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