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Optimized Whole-Genome Amplification Strategy for Extremely AT-Biased Template

19 Sept 2014

Abstract excerpt

Pathogen genome sequencing directly from clinical samples is quickly gaining importance in genetic and medical research studies. However, low DNA yield from blood-borne pathogens is often a limiting factor. The problem worsens in extremely base-biased genomes such as the AT-rich Plasmodium falciparum. We present a strategy for whole-genome amplification (WGA) of low-yield samples from P. falciparum prior to...

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PMID: 25240466
DOI: 10.1093/dnares/dsu028

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