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Optimizing illumina next-generation sequencing library preparation for extremely at-biased genomes

1 Jan 2012

Abstract excerpt

BACKGROUND: Massively parallel sequencing technology is revolutionizing approaches to genomic and genetic research. Since its advent, the scale and efficiency of Next-Generation Sequencing (NGS) has rapidly improved. In spite of this success, sequencing genomes or genomic regions with extremely biased base composition is still a great challenge to the currently available NGS platforms. The genomes of some...

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PMID: 22214261
DOI: 10.1186/1471-2164-13-1

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