Article

Optimization of whole-genome sequencing of <i>Plasmodium falciparum</i> from low-density dried blood spot samples

2019-11-08

Abstract excerpt

<h4>Background</h4> Whole-genome sequencing (WGS) is becoming increasingly useful to study the biology, epidemiology, and ecology of malaria parasites. Despite ease of sampling, DNA extracted from dried blood spots (DBS) has a high ratio of human DNA compared to parasite DNA, which poses a challenge for downstream genetic analyses. We evaluated the effects of multiple methods for DNA extraction, digestion of meth...

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Literature Corpus work: 2ce8d79a-4297-50a4-ac7a-e46dc2862696
DOI: 10.1101/835389

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