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Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of <i>Plasmodium vivax</i> from Unprocessed Clinical Samples

8 Feb 2017

Abstract excerpt

Whole-genome sequencing (WGS) of microbial pathogens from clinical samples is a highly sensitive tool used to gain a deeper understanding of the biology, epidemiology, and drug resistance mechanisms of many infections. However, WGS of organisms which exhibit low densities in their hosts is challenging due to high levels of host genomic DNA (gDNA), which leads to very low coverage of the microbial genome. WGS of...

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PMID: 28174312
DOI: 10.1128/mbio.02257-16

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