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Optimization of whole-genome sequencing of Plasmodium falciparum from low-density dried blood spot samples

26 Feb 2021

Abstract excerpt

BACKGROUND: Whole-genome sequencing (WGS) is becoming increasingly useful to study the biology, epidemiology, and ecology of malaria parasites. Despite ease of sampling, DNA extracted from dried blood spots (DBS) has a high ratio of human DNA compared to parasite DNA, which poses a challenge for downstream genetic analyses. The effects of multiple methods for DNA extraction, digestion of methylated DNA, and...

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PMID: 33637093
DOI: 10.1186/s12936-021-03630-4

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