Complete telomere-to-telomere <i>de novo</i> assembly of the <i>Plasmodium falciparum</i> genome through long-read (&gt;11 kb), single molecule, real-time sequencing

Abstract excerpt

The application of next-generation sequencing to estimate genetic diversity of Plasmodium falciparum, the most lethal malaria parasite, has proved challenging due to the skewed AT-richness [∼80.6% (A + T)] of its genome and the lack of technology to assemble highly polymorphic subtelomeric regions that contain clonally variant, multigene virulence families (Ex: var and rifin). To address this, we performed...

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