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Article

Mst1 participates in the atherosclerosis progression through macrophage autophagy inhibition and macrophage apoptosis enhancement.

Journal of molecular and cellular cardiology - 1 Sept 2016

Wang Tingting, Zhang Lei, Hu Jianqiang, Duan Yu, Zhang Mingming, Lin Jie, Man Wanrong, Pan Xietian, Jiang Zhenhua, Zhang Guoyong, Gao Beilei, Wang Haichang, Sun Dongdong

Abstract excerpt

Emerging evidence favors the notion that macrophage autophagy plays a prominent role in the pathogenesis of vulnerable plaque, suggesting the therapeutic potential of targeting autophagy in atherosclerosis. Here ApoE(-/-) mice were crossed with Mst1 knockout or Mst1 Tg mice to generate ApoE(-/-):Mst1(-/-) and ApoE(-/-):Mst1Tg mice. All animals were fed high-fat-diet for 4months to induce arterial atherosclerosis....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27496379
DOI: 10.1016/j.yjmcc.2016.08.002

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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