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Article

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signaling

28 Aug 2014

Abstract excerpt

Nonsteroidal anti-inflammatory drug-activated gene (NAG-1) or GDF15 is a divergent member of the transforming growth factor beta (TGF-β) superfamily and mice expressing hNAG-1/hGDF15 have been shown to be resistant to HFD-induced obesity and inflammation. This study investigated if hNAG-1 increases lifespan in mice and its potential mechanisms. Here we report that female hNAG-1 mice had significantly increased...

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PMID: 25239873
DOI: 10.18632/aging.100687

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