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The age-dependent regulation of pancreatic islet landscape is fueled by a HNF1a-immune signaling loop

31 May 2024

Abstract excerpt

Animal longevity is a function of global vital organ functionality and, consequently, a complex polygenic trait. Yet, monogenic regulators controlling overall or organ-specific ageing exist, owing their conservation to their function in growth and development. Here, by using pathway analysis combined with wet-biology methods on several dynamic timelines, we identified Hnf1a as a novel master regulator of the...

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PMID: 38825059
DOI: 10.1016/j.mad.2024.111951

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