Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice.

Scientific reports - 22 Jul 2021

Lertpatipanpong Pattawika, Lee Jaehak, Kim Ilju, Eling Thomas, Oh Seung Yeon, Seong Je Kyung, Baek Seung Joon

Abstract excerpt

Nonsteroidal anti-inflammatory drug-activated gene-1 (NAG-1) plays a role in various diseases. Here, the anti-diabetic effects of NAG-1 were evaluated using a high-fat diet/streptozotocin-induced diabetic mouse model. NAG-1-overexpressing transgenic (NAG-1 Tg) mice exhibited lower body weight, fasting blood glucose levels, and serum insulin levels than wild-type (WT) mice. The homeostatic model assessment of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus, Experimental
Share to Diet, High-Fat

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Susceptibility

Share to Dyslipidemias

Share to Insulin Resistance

Share to Pancreas

Share to Streptozocin

Source

Open in PubMed Open full text

Identifiers

PMID: 34294853
DOI: 10.1038/s41598-021-94581-y
PMCID: PMC8298384

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The anti-diabetic effects of NAG-1/GDF15 on HFD/STZ-induced mice.PMID 34294853Read ↗

NAG-1/GDF15 Exerts Anti-diabetic Effects through the Insulin Signaling PathwaySemantic proximity Read ↗

hNAG-1 increases lifespan by regulating energy metabolism and insulin/IGF-1/mTOR signalingSemantic proximity Read ↗

NAG-1/GDF15 Transgenic Mouse Has Less White Adipose Tissue and a Reduced Inflammatory ResponseSemantic proximity Read ↗

JinLiDa granules alleviates cardiac hypertrophy and inflammation in diabetic cardiomyopathy by regulating TP53Semantic proximity Read ↗

Galangin Resolves Cardiometabolic Disorders Through Modulation of AdipoR1/COX-2/ NF-κB Expressions in High-Fat Diet Fed RatsSemantic proximity Read ↗

α-linolenic Acid Regulates Macrophages NF-κB/NLRP3 Signal Pathway via Binding GPR120 to Inhibit Inflammation in Type 2 DiabetesSemantic proximity Read ↗

Neem seed oil improves redox imbalance and exhibits antihyperglycemic, antilipidemic, and anti-inflammatory properties in a rodent model of type 2 diabetesSemantic proximity Read ↗

Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats.Semantic proximity Read ↗

G004, a synthetic sulfonylurea compound, exerts anti-atherosclerosis effects by targeting SIRT1 in ApoE-/- mice.Semantic proximity Read ↗

GDF11 alleviates pathological myocardial remodeling in diabetic cardiomyopathy through SIRT1-dependent regulation of oxidative stress and apoptosisSemantic proximity Read ↗

Tirzepatide but not Semaglutide Ameliorates Hepatic Steatosis and Inflammatory Infiltration in a Mouse Model of MASLD via Inhibition of the CCL2/CCR2-PI3K-Akt PathwaySemantic proximity Read ↗

Pioglitazone Hydrochloride Extends the Lifespan of Caenorhabditis elegans by Activating DAF‐16/FOXO‐ and SKN‐1/NRF2‐Related Signaling PathwaysSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.