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microRNA-449a reduces growth hormone-stimulated senescent cell burden through PI3K-mTOR signaling

28 Mar 2023

Abstract excerpt

Cellular senescence, a hallmark of aging, has been implicated in the pathogenesis of many major age-related disorders, including neurodegeneration, atherosclerosis, and metabolic disease. Therefore, investigating novel methods to reduce or delay the accumulation of senescent cells during aging may attenuate age-related pathologies. microRNA-449a-5p (miR-449a) is a small, noncoding RNA down-regulated with age in...

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PMID: 36976763
DOI: 10.1073/pnas.2213207120

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