Article

In vivo CRISPR screening identifies SAGA complex members as key regulators of hematopoiesis

2022-07-22

Abstract excerpt

The biological mechanisms that sustain the vast blood production required for healthy life remain incompletely understood. To search for novel regulators of hematopoiesis, we performed genome-wide in vivo hematopoietic stem cell (HSC)-based CRISPR knockout screens for regulators of hematopoiesis. We discovered SAGA complex members, including Tada2b and Taf5l , as key regulators of hematopoiesis. Loss of Tada2b...

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Identifiers and source

Literature Corpus work: 4f156d91-4227-5f23-92ce-2facb59358ee
DOI: 10.1101/2022.07.22.501030

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