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Article

DDX41 is needed for pre- and postnatal hematopoietic stem cell differentiation in mice

17 Mar 2022

Abstract excerpt

DDX41 is a tumor suppressor frequently mutated in human myeloid neoplasms, but whether it affects hematopoiesis is unknown. Using a knockout mouse, we demonstrate that DDX41 is required for mouse hematopoietic stem and progenitor cell (HSPC) survival and differentiation, particularly of myeloid lineage cells. Transplantation of Ddx41 knockout fetal liver and adult bone marrow (BM) cells was unable to rescue mice...

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PMID: 35303436
DOI: 10.1016/j.stemcr.2022.02.010

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