Article
Dissecting the genetics of chronic mucus hypersecretion in smokers with and without COPD.
The European respiratory journal - 1 Jan 2015
Dijkstra Akkelies E, Boezen H Marike, van den Berge Maarten, Vonk Judith M, Hiemstra Pieter S, Barr R Graham, Burkart Kirsten M, Manichaikul Ani, Pottinger Tess D, Silverman Edward K, Cho Michael H, Crapo James D, Beaty Terri H, Bakke Per, Gulsvik Amund, Lomas David A, Bossé Yohan, Nickle David C, Paré Peter D, de Koning Harry J, Lammers Jan-Willem, Zanen Pieter, Smolonska Joanna, Wijmenga Ciska, Brandsma Corry-Anke, Groen Harry J M, Postma Dirkje S
Abstract excerpt
Smoking is a notorious risk factor for chronic mucus hypersecretion (CMH). CMH frequently occurs in chronic obstructive pulmonary disease (COPD). The question arises whether the same single-nucleotide polymorphisms (SNPs) are related to CMH in smokers with and without COPD. We performed two genome-wide association studies of CMH under an additive genetic model in male heavy smokers (≥20 pack-years) with COPD...
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