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Epigenetic reprogramming of airway macrophages promotes polarization and inflammation in muco-obstructive lung disease

11 Nov 2021

Abstract excerpt

Lung diseases, such as cystic fibrosis and COPD, are characterized by mucus obstruction and chronic airway inflammation, but their mechanistic link remains poorly understood. Here, we focus on the function of the mucostatic airway microenvironment on epigenetic reprogramming of airway macrophages (AM) and resulting transcriptomic and phenotypical changes. Using a mouse model of muco-obstructive lung disease...

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PMID: 34764283
DOI: 10.1038/s41467-021-26777-9

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