Article

A novel polygenic risk score model based on the protein interactions: An application on psoriasis

2023-06-07

Abstract excerpt

<h4>Background: </h4> Polygenic Risk Scores (PRS) have been widely applied for predicting an individual’s genetic risk to a phenotype. Here, we develop a biologically-driven PRS in the UK BioBank cohort through validated protein interactions (PPI) and network construction for psoriasis, incorporating variants mapped to the interacting genes. We compare our PPI-PRS approach to conventional PRS calculations through...

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Literature Corpus work: 8a11aef5-4a34-587e-ace6-a735d6e4b2cd
DOI: 10.21203/rs.3.rs-2902091/v1

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